A tainted food supply has turned the world in a force of zombies on the prowl for the few survivors of the human race. Columbus (Jesse Eisenberg) is an enterprising zombie survivor with some steadfast rules of engagement, though his phobias could prove his undoing. Columbus wants to find his parents, but along the way he meets Tallahassee (Woody Harrelson), a knowledgeable zombie expert killer. His creative energy helps him eradicate zombies with élan. Two sisters named Wichita (Emma Stone) and Little Rock (Abigail Breslin) are not to be trusted, but team up with the men. They believe there is a zombie-free zone in Los Angeles and will do whatever it takes to get there.