The October 31, in Haddonfield, Illinois, during the evening of Halloween, the life of Michael Myers (Daeg Faerch), a 10 years old boy, change forever. Disturbed by morbid impulses, molested by his classmates, harassed by his father, tormented by his older sister, he puts a latex mask and, in an access of madness, murders several members of his family with a kitchen knife. As a result of that night's nightmare, the Dr. Loomis (Malcolm McDowell), a brilliant shrink, decide to help him. But Michael kills a nurse, which precipitates the suicide of her desperate mother.17 years later, the October 31, Michael is still hidden behind a mask and locked up in his silence. He escapes from the psychiatric prison where he grew up and start his massacre. Convinced that he is an incarnation of evil, Dr. Loomis decides to stop him. That leads him directly to Haddonfield, where the little sister of Michael, Laurie (Scout Taylor-Compton)is still alive.