Best friends Carrie (Sarah Jessica Parker), Charlotte (Kristin Davis), Miranda (Cynthia Nixon), and Samantha (Kim Cattrall) are coping with new challenges in their lives. Carrie is facing a new role in life, as a married woman, and is facing the frightening prospect of domesticity. Charlotte and her husband Harry (Evan Handler) are facing a child entering her terrible twos and a very forward nanny whose presence may threaten their marriage. Miranda is struggling to advance in her job thanks to a new, difficult boss, and Samantha is still looking for love, or at least for some fun. When the girls get to go on a trip to Abu Dhabi thanks to Samantha, they're out to have some fun and forget their current woes.